Related Experiment Video

Updated: May 23, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

The anticancer effects of resveratrol: modulation of transcription factors

Nichelle C Whitlock1, Seung Joon Baek

  • 1Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA.

Nutrition and Cancer
|April 10, 2012
PubMed

Insights

Resveratrol, a dietary compound, shows anticancer promise by modulating signaling pathways and transcription factors. Further research into these mechanisms is crucial for understanding its chemopreventive and chemotherapeutic potential in cancer.

Area of Science:

  • Nutritional Biochemistry
  • Molecular Oncology
  • Cancer Prevention

Background:

  • Resveratrol (3, 4', 5-trihydroxystilbene) is a natural phytoalexin found in the diet.
  • It exhibits documented chemopreventive and chemotherapeutic effects across various cancers.
  • The precise molecular mechanisms underlying resveratrol's anticancer activities remain incompletely elucidated.

Purpose of the Study:

  • To review the current understanding of resveratrol's molecular targets, focusing on transcription factors.
  • To elucidate how resveratrol influences transcriptional regulation in cancer chemoprevention and therapy.
  • To consolidate knowledge on resveratrol's role in modulating key cancer-related signaling pathways.

Main Methods:

  • Literature review of studies investigating resveratrol's molecular targets.
  • Analysis of research on transcription factors affected by resveratrol.
  • Synthesis of findings related to resveratrol's impact on carcinogenesis and cancer progression pathways.

Main Results:

  • Resveratrol impacts multiple signal transduction pathways involved in tumorigenesis and carcinogenesis.
  • Key molecular targets include transcription factors that regulate gene expression relevant to cancer.
  • Resveratrol's anticancer effects are linked to inhibiting carcinogen activation, inducing detoxification, promoting growth arrest and apoptosis, and suppressing pro-inflammatory pathways.

Conclusions:

  • Resveratrol's collective action on various molecular targets, particularly transcription factors, is critical for its anticancer properties.
  • Understanding these targets is essential for optimizing resveratrol's use in chemoprevention and chemotherapy.
  • This review highlights the significance of transcriptional regulation in resveratrol's multifaceted anticancer effects.

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

Related Concept Videos

Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...