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Updated: May 23, 2026
08:47
Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Rotaxanes and biofunctionalized pseudorotaxanes via thiol-maleimide click chemistry
Umesh Choudhary1, Brian H Northrop
1Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459, USA.
Organic Letters
|April 10, 2012
Abstract:
Base-catalyzed thiol-maleimide click chemistry has been applied to the synthesis of neutral donor-acceptor [2]rotaxanes in good yield. This method is extended further to the synthesis of a glutathione-functionalized [2]pseudorotaxane, a precursor to integrated conjugates of interlocked molecules with proteins and enzymes.
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