Generation of transplantable striatal projection neurons from human ESCs
Malin Parmar1, Anders Björklund
1Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden.
Abstract:
In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.
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