Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of the SerpinB3/protease-activated receptor 2 axis reduces liver cancer development and affects lipid metabolism.

British journal of cancer·2026
Same author

Trefoil Factor-3 Is a Hypoxia-Triggered Pro-Tumorigenic Factor in Hepatoblastoma.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

The role of OSM/OSMRβ axis in shaping the tumor microenvironment favoring MASLD-related HCC immune evasion.

Hepatology (Baltimore, Md.)·2026
Same author

Long-term outcome and risk stratification in compensated advanced chronic liver disease after HCV-cure.

Hepatology (Baltimore, Md.)·2025
Same author

Long-term outcome and risk stratification in compensated advanced chronic liver disease after HCV-cure.

Hepatology (Baltimore, Md.)·2024
Same author

Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis.

Frontiers in immunology·2024
Same journal

Needle-based confocal laser endomicroscopy and artificial intelligence in pancreatic cystic lesions: Insights and clinical advances.

Best practice & research. Clinical gastroenterology·2026
Same journal

Evidence-based approach to the diagnosis, management and surveillance of pancreatic cystic lesions: from the guidelines to the clinical practice.

Best practice & research. Clinical gastroenterology·2026
Same journal

Pancreatic cystic lesions in hereditary syndromes: Diagnostic role of endoscopic ultrasound.

Best practice & research. Clinical gastroenterology·2026
Same journal

Predictive risk models for the diagnosis and cancer progression of pancreatic cysts.

Best practice & research. Clinical gastroenterology·2026
Same journal

Preface.

Best practice & research. Clinical gastroenterology·2026
Same journal

Endoscopic ultrasound-guided treatment of pancreatic lesions.

Best practice & research. Clinical gastroenterology·2026
See all related articles

Related Experiment Video

Updated: May 23, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Stem cells in liver failure.

Francesco P Russo1, Maurizio Parola

  • 1Department of Surgical and Gastroenterological Sciences, Gastroenterology Unit, University of Padova, Padova, Italy. francescopaolo.russo@unipd.it

Best Practice & Research. Clinical Gastroenterology
|April 10, 2012
PubMed
Summary
This summary is machine-generated.

Cellular therapy offers a promising alternative for liver failure, addressing donor liver shortages. Research explores various cell types, including hepatocytes and stem cells, for transplantation to treat liver diseases.

More Related Videos

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
07:37

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Published on: June 11, 2019

Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

Related Experiment Videos

Last Updated: May 23, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
07:37

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Published on: June 11, 2019

Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

Area of Science:

  • Hepatology and Regenerative Medicine
  • Cellular Therapeutics

Background:

  • Orthotopic liver transplantation (OLT) is the primary treatment for acute liver failure (ALF), chronic liver disease (CLD), and hepatocellular carcinoma (HCC).
  • High ALF mortality and rising cirrhosis prevalence contribute to liver failure, exacerbated by a projected donor liver shortage.
  • These factors necessitate exploring alternative therapeutic strategies for liver failure.

Purpose of the Study:

  • To review the feasibility and efficacy of cellular therapy as an alternative to OLT for liver failure.
  • To summarize findings from experimental and clinical studies using various cell sources for liver regeneration.

Main Methods:

  • Overview of recent experimental and clinical studies on cellular therapy for liver failure.
  • Analysis of transplantable cell sources including adult/embryonic hepatocytes, hepatic stem/progenitor cells, induced pluripotent stem (iPS) cells, and extrahepatic stem cells.

Main Results:

  • Various cell types, including hepatocytes and stem cells, have been investigated as potential treatments for liver failure.
  • Studies assess the efficacy of these cells in preclinical models and clinical trials.

Conclusions:

  • Cellular therapy presents a viable alternative to OLT, particularly given the anticipated donor organ scarcity.
  • Further research into different cell sources is crucial for advancing regenerative medicine for liver diseases.