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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: May 23, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

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Published on: November 7, 2020

Tolerance in liver transplantation.

G Alex Bishop1, Patrick D Bertolino, David G Bowen

  • 1Collaborative Transplantation Laboratory, Royal Prince Alfred Hospital and the University of Sydney, Australia. alex.bishop@sydney.edu.au

Best Practice & Research. Clinical Gastroenterology
|April 10, 2012
PubMed
Summary
This summary is machine-generated.

Operational tolerance (OT) after liver transplantation (LTX) is common but varies significantly. This review explores factors influencing OT rates and monitoring strategies in LTX patients.

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Area of Science:

  • Transplantation immunology
  • Gastroenterology
  • Clinical research

Background:

  • Operational tolerance (OT) is more frequent in liver transplant (LTX) recipients than other organ transplants.
  • Reported rates of OT in LTX patients vary widely, from under 5% to 15%.

Purpose of the Study:

  • To review existing literature on operational tolerance in liver transplantation.
  • To identify factors contributing to the variability in OT rates across different centers and patient populations.
  • To discuss strategies for increasing OT likelihood and monitoring OT in LTX patients.

Main Methods:

  • Systematic review of published reports on liver transplant operational tolerance.
  • Comparative analysis of factors influencing OT rates, including immunosuppression weaning protocols and patient demographics.
  • Examination of current OT monitoring approaches in LTX.

Main Results:

  • Significant variability exists in reported OT rates among liver transplant centers.
  • Factors such as timing and speed of immunosuppression weaning, type of immunosuppression used, and patient population influence OT rates.
  • No single factor definitively explains the wide range of OT occurrences.

Conclusions:

  • Understanding the factors influencing OT variability is crucial for optimizing LTX outcomes.
  • Further research into standardized protocols for weaning immunosuppression and monitoring OT may improve patient management.
  • Developing strategies to enhance OT likelihood could reduce long-term immunosuppression-related complications in LTX recipients.