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Updated: May 23, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Short latency afferent inhibition associated with cortical compression and memory impairment in patients with chronic
Yukari Kawasaki1, Minoru Fujiki, Hiroshi Ooba
1Department of Neurosurgery, School of Medicine, Oita University, 1-1 Idaigaoka, Hasamamach, Oita 879-5593, Japan.
Objective:
To evaluate the cortical excitability in patients with mild cortical compression.
Methods:
The present study used short interval intracortical inhibition (SICI), intracortical facilitation (ICF), and short latency afferent inhibition (SAI) to evaluate motor cortex excitability in 16 chronic subdural hematoma (CSDH) patients with memory impairment and compared the data with those of 16 healthy controls.
Results:
SAI was reduced in patients compared with controls (99±14 vs. 47±11% of the test size; p<0.0001, unpaired t-test). CSDH patients tended to have a high resting motor threshold and less pronounced SICI and ICF than controls, but these differences were not significant. Treatment of hematoma improved memory impairment and SAI in CSDH patients with wide individual variations that ranged from an increase of 74% to 17% of test size.
Conclusion:
These findings suggest that measuring SAI may provide a means of probing the integrity of cortical cholinergic networks in a compressed human brain.
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