Related Experiment Video
Updated: May 23, 2026
10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
[Angle-closure glaucoma secondary to topiramate use].
M Rodríguez-Blanco1, A Piñeiro, M Bande
1Servicio de Oftalmología, Hospital de Conxo, Complexo Hospitalario Universitario de Santiago de Compostela, La Coruña, España. meyerblanco@yahoo.es
Archivos De La Sociedad Espanola De Oftalmologia
|April 10, 2012
Summary
Topiramate can cause acute myopia and angle-closure glaucoma due to choroidal effusion. Discontinuation of topiramate led to resolution of these vision problems.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Topiramate is an anticonvulsant and migraine prophylactic medication.
- Ocular side effects of topiramate, though rare, warrant investigation.
Observation:
- A 42-year-old patient developed acute myopia and closed-angle glaucoma one week after initiating topiramate treatment.
- Ultrasound biomicroscopy demonstrated bilateral angle closure and choroidal effusion.
Findings:
- Topiramate is implicated as the cause of acute myopia and angle-closure glaucoma.
- Choroidal effusion is the likely mechanism behind these ocular complications.
- Cessation of topiramate resulted in the resolution of the patient's clinical symptoms.
Implications:
- Topiramate poses a risk for inducing acute myopia and angle-closure glaucoma.
- Ultrasound biomicroscopy is a valuable diagnostic tool for identifying and monitoring topiramate-induced ocular changes.
- Clinicians should consider topiramate's potential ocular toxicity in patients presenting with acute visual disturbances.
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