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Published on: December 2, 2015
Comparing the neural bases of self-referential processing in typically developing and 22q11.2 adolescents
Maude Schneider1, Martin Debbané, Annalaura Lagioia
1Office Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, 1 David Dufour, CP 50, 1211 Geneva 8, Switzerland.
Adolescents with 22q11.2 deletion syndrome show reduced brain activity in self-processing regions. This hypoactivation is linked to social difficulties and increased schizophrenia risk.
Area of Science:
- Neuroscience
- Developmental Psychology
- Psychiatry
Background:
- Adolescence involves significant self-concept reorganization.
- Atypical self-reflective processing may increase risk for psychological disorders and social impairment.
- 22q11.2 deletion syndrome (22q11DS) is linked to social difficulties and schizophrenia risk.
Purpose of the Study:
- Investigate neural bases of self- and other-related processing in adolescents.
- Compare typically developing adolescents with those with 22q11DS.
- Examine links between neural activity, social function, and schizophrenia risk.
Main Methods:
- Functional magnetic resonance imaging (fMRI) paradigm.
- Adolescents judged adjectives applied to self, best friend, or fictional character.
- Compared brain activation between control and 22q11DS groups.
Main Results:
- Typically developing adolescents showed strong cortical midline structure (CMS) activation for self-related processing.
- 22q11DS group exhibited hypoactivation in CMS and striatum during self-processing.
- Anterior cingulate cortex hypoactivation correlated with schizophrenia symptom severity.
Conclusions:
- Self-related processing differs in adolescents with 22q11DS compared to controls.
- Neural differences may underlie social and cognitive challenges in 22q11DS.
- Findings inform understanding of schizophrenia development in at-risk populations.
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