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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

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Related Experiment Video

Updated: May 23, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: August 30, 2018

Combating antimicrobial resistance: antimicrobial stewardship program in Taiwan.

Shu-Hui Tseng1, Chun-Ming Lee, Tzou-Yien Lin

  • 1Centers for Disease Control, Department of Health, Taiwan, ROC.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|April 10, 2012
PubMed
Summary

Combating antimicrobial resistance requires national commitment and effective health policies. Taiwan

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Last Updated: May 23, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

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Published on: August 30, 2018

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

Area of Science:

  • Public Health
  • Infectious Diseases
  • Health Policy

Background:

  • Multi-drug-resistant organisms (MDROs) pose a significant global public health threat.
  • Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) present major challenges in Taiwan.
  • Government health policies and healthcare systems are critical for controlling AMR.

Purpose of the Study:

  • To analyze and review antibiotic resistance policies in Taiwan, USA, and WHO.
  • To evaluate a draft antimicrobial stewardship program for controlling AMR in Taiwan.
  • To identify strategies for limiting the spread of MDROs and reducing antibiotic-resistant bacteria.

Main Methods:

  • Policy analysis and review of international and national strategies.
  • Examination of Taiwan's antimicrobial stewardship program components.
  • Assessment of surveillance, infection control, and regulatory measures.

Main Results:

  • Taiwan's antimicrobial stewardship program involves a national task force, resistance management strategies, surveillance, infection control, and regulatory enforcement.
  • Audit of antimicrobial use is integrated through hospital accreditation and national health insurance.
  • A multifaceted, evidence-based approach is being adopted by Taiwan CDC.

Conclusions:

  • Effective control of antimicrobial resistance necessitates a comprehensive national strategy.
  • Taiwan's antimicrobial stewardship program integrates various components to combat AMR.
  • Continuous effort and stakeholder collaboration are crucial to limit MDRO spread and reduce antibiotic resistance.