Related Experiment Video
Updated: May 23, 2026
Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
Published on: June 16, 2023
Preoperative autologous blood donation and acute normovolemic hemodilution affect intraoperative blood loss during
Yoko Iwase1, Atsushi Kohjitani, Akina Tohya
1Department of Dental Anesthesia, Kagoshima University Medical and Dental Hospital, Japan.
Introduction:
This study aimed to determine the effects of acute normovolemic hemodilution (ANH) using low-molecular-weight hydroxyethyl starch (LMW-HES) on intraoperative blood loss in patients who had received preoperative autologous blood donation (PABD) and had undergone sagittal split ramus osteotomy (SSRO).
Methods:
Patients who had undergone SSRO were analyzed. All 250 patients received PABD of 400-800 mL until 2 weeks before surgery. ANH was performed by withdrawing whole blood, which was replaced by the same volume of LMW-HES. ANH was performed in 197 cases for 200 mL replacement (ANH-200) and in 5 cases for 400 mL replacement (ANH-400); it was not performed in 48 cases (ANH-0).
Results:
Blood loss in ANH-200 was greater than that in ANH-0, despite no differences in hemoglobin concentrations at pre- and post-PABD, prothrombin time, activated partial thromboplastin time, fibrinogen and platelet counts between the groups before surgery. Blood loss increased as the total withdrawn blood (sum of PABD and ANH) increased.
Conclusion:
Increased intraoperative blood loss was associated with total withdrawn blood before the operation as well as ANH.
