Facticial panniculitis and Löfgren's syndrome: a case
Carolina Diez Morrondo1, Natalia Palmou Fontana, José Manuel Lema Gontad
1Servicio de Reumatología, Complejo Hospitalario Universitario A Coruña, A Coruña, España. caroldiez81@hotmail.com
Reumatologia Clinica
|April 10, 2012
Summary
A patient with silicone buttock implants developed joint pain, fever, and skin lesions. Biopsies revealed silicone-induced panniculitis and erythema nodosum, with granulomatous inflammation found in lymph nodes.
Area of Science:
- Rheumatology
- Dermatology
- Pathology
Background:
- Silicone implants are widely used for cosmetic and reconstructive purposes.
- Systemic complications associated with silicone implants are rare but can be severe.
- This case highlights a potential link between silicone implants and inflammatory conditions.
Observation:
- A patient presented with polyarticular joint pain, fever, and cutaneous lesions.
- The patient had undergone silicone buttock augmentation three years prior.
- Skin biopsies showed facticial panniculitis (silicone-induced) and erythema nodosum.
Findings:
- Imaging revealed bilateral hilar lymphadenopathy.
- Transbronchial biopsy confirmed granulomatous inflammation.
- The patient responded well to conservative management, including rest and anti-inflammatory drugs.
Implications:
- This case suggests silicone implants may trigger systemic inflammatory responses.
- Further research is needed to understand the mechanisms of silicone-related autoimmunity.
- Conservative management may be effective, potentially avoiding implant removal in select cases.
Related Concept Videos
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:17Gastritis-II: Pathophysiology
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...