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Updated: May 23, 2026
07:11
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
Right ventricular dysfunction in adolescents with mild cystic fibrosis
Antonio Baño-Rodrigo1, Antonio Salcedo-Posadas, Jose R Villa-Asensi
1Department of Cardiology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain. antonio_bano@hotmail.com
Summary
Right ventricle (RV) dysfunction in cystic fibrosis (CF) is present even in early stages. These early RV changes in CF patients are subclinical and do not correlate with disease severity markers.
Area of Science:
- Cardiology
- Pulmonology
- Pediatrics
Background:
- Cystic fibrosis (CF) is known to cause progressive right ventricle (RV) deterioration.
- The onset of RV dysfunction in CF patients remains unclear, particularly in those with mild respiratory disease.
Purpose of the Study:
- To investigate RV function in adolescent CF patients with mild respiratory disease.
- To identify early structural and functional changes in the RV of CF patients.
Main Methods:
- Prospective Color-Doppler-Echocardiographic studies were conducted in 37 adolescent CF patients and 40 age-matched controls.
- Echocardiographic findings were correlated with pulmonary function tests, genotype, bacterial colonization, pancreatic status, and clinical scores.
Main Results:
- CF patients exhibited abnormal echocardiographic parameters compared to controls.
- Doppler analysis revealed elevated pulmonary artery pressure, impaired RV relaxation, and reduced systolic function in CF patients.
- No significant correlation was found between RV abnormalities and clinical parameters, PFT, genotype, bacterial colonization, or pancreatic status.
Conclusions:
- RV structural and functional abnormalities may be present in early-stage cystic fibrosis.
- These RV changes in CF patients are subclinical.
- Early RV abnormalities in CF do not correlate with disease severity indicators such as clinical scores, PFT, genotype, bacterial colonization, or pancreatic insufficiency.
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