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Updated: May 23, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
An overview of values for the threshold of toxicological concern
1European Centre for Ecotoxicology and Toxicology of Chemicals-ECETOC, Av. E. Van Nieuwenhuyse 4, B-1160 Brussels, Belgium. christa.hennes@ecetoc.org
Abstract:
An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/exposure scenario and provides, in particular, key information on the underlying databases. It is aimed to support the application of the TTC approach in the risk assessment of chemicals whereby it is important to be aware under which circumstances a certain TTC value can be applied. Some recommendations for potential future developments to further improve the TTC approach are also being made.
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