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Updated: May 23, 2026
A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats
Published on: November 6, 2018
Repeated paired-testing impairs extinction of morphine-induced conditioned place preference dependent on the
Jian-Jun Zhang1, Xiang Ma, Long-Chuan Yu
1Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.
Abstract:
Using exposure to morphine- and saline-paired sides alternatively as the extinction training procedure, we find that post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference (CPP) dependent on the retrieval-extinction training intervals. Here, we examine the influence of post-retrieval extinction training with repeated paired testing on extinction of morphine-induced CPP of rats. Our results demonstrate that paired-testing with a 10-min inter-test interval does not influence the extinction of CPP, while post-retrieval extinction training blocks the extinction of CPP with a 3-h retrieval-extinction interval. These results strongly indicate that the interval between exposure trials influences the outcome of exposure therapy in addiction treatment.
