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γ knife surgery versus reoperation for recurrent glioblastoma multiforme
Bente Sandvei Skeie1, Per Øyvind Enger, Jan Brøgger
1Department of Surgical Sciences, Haukeland University Hospital, Bergen, Norway. bsai@helse-bergen.no
World Neurosurgery
|April 10, 2012
Summary
Gamma Knife surgery (GKS) offers a survival benefit and lower complication rates for recurrent glioblastoma multiforme (GBM) compared to reoperation. This minimally invasive option may be preferable for managing recurrent GBMs.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Recurrent glioblastoma multiforme (GBM) management remains controversial.
- Reoperation and Gamma Knife Surgery (GKS) are potential treatment options.
- Limited comparative data exists for GKS versus reoperation in recurrent GBM.
Purpose of the Study:
- To compare the efficacy and safety of GKS and reoperation for recurrent GBM.
- To evaluate survival rates and complication profiles of both treatment modalities.
Main Methods:
- Retrospective review of 77 patients with recurrent GBM treated between 1996-2007.
- Patients underwent Gamma Knife Surgery (GKS), reoperation, or both.
- Survival and complication data were analyzed.
Main Results:
- GKS showed a longer median time to tumor progression compared to resection (P=0.009).
- Median survival post-retreatment was 12 months with GKS vs. 6 months with reoperation (P=0.001).
- Complication rates were significantly lower with GKS (9.8%) than reoperation (25.2%).
Conclusions:
- Gamma Knife Surgery (GKS) presents a viable alternative to open surgery for recurrent GBM.
- GKS offers a potential survival benefit and a lower complication rate.
- GKS may be particularly suitable for smaller recurrent GBMs.
