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In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Related Experiment Video

Updated: May 23, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

[Development of integrated support software for drug validation].

M A Campos Fernández de Sevilla1, F Tutau Gómez, M Gallego Úbeda

  • 1Servicio de Farmacia, Hospital Universitario del Henares, Coslada, Madrid, España. mangeles.campos@salud.madrid.org

Farmacia Hospitalaria : Organo Oficial De Expresion Cientifica De La Sociedad Espanola De Farmacia Hospitalaria
|April 10, 2012
PubMed
Summary
This summary is machine-generated.

This study developed automated software to detect adverse drug-related events (ADRE) in hospital patients. The tool identifies at-risk individuals and suggests treatment modifications, enhancing drug safety.

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Last Updated: May 23, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Published on: December 1, 2020

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Area of Science:

  • Clinical Pharmacy
  • Health Informatics
  • Pharmacovigilance

Context:

  • Hospital pharmacy departments face challenges in proactively identifying patients at risk of adverse drug-related events (ADRE).
  • Existing methods for ADRE detection are often manual, time-consuming, and may not cover the entire patient population.
  • The integration of clinical data and treatment information is crucial for effective patient safety monitoring.

Purpose:

  • To develop and describe a novel software tool for the automated detection of specific adverse drug-related events (ADRE) across all hospital patients.
  • To design a system capable of integrating data from clinical history, prescription management, and custom-defined criteria for ADRE identification.
  • To create a tool that assists pharmacists by automatically flagging patients at risk and recommending treatment adjustments.

Summary:

  • A software tool was developed to automatically detect adverse drug-related events (ADRE) in hospital patients, focusing on specific scenarios like kidney failure or enteral feeding tube use.
  • The software integrates data from clinical history (SELENE®), treatment prescriptions (Farmatools®), and designed tables to identify at-risk patients.
  • Upon detection, the system recommends modified treatments to pharmacists, enabling a proactive approach to drug safety.

Impact:

  • The developed software serves as a valuable drug validation tool, potentially reducing medication errors and improving patient outcomes.
  • Automating ADRE detection enhances the efficiency and scope of pharmacovigilance activities within a hospital setting.
  • This tool empowers pharmacists with real-time, data-driven insights to optimize patient treatment and mitigate risks associated with drug administration.