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WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway

Ping Zhang1, Renbing Jia, Lei Ying

  • 1Department of Biochemistry and Molecular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, PR China.

Molecular Medicine Reports
|April 10, 2012
PubMed
Summary

The WW domain-containing oxidoreductase (WWOX) gene, a potential tumor suppressor, triggers apoptosis in lung cancer cells. This study reveals WWOX activates the mitochondrial pathway, leading to programmed cell death.

Keywords:
WW domain-containing oxidoreductasemitochondrionapoptosis

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