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Immunomodulators for multiple sclerosis may ameliorate spinal bone loss.

M J McKenna¹, B Murray, R Lonergan

¹DXA Unit, St. Vincent's University Hospital, Dublin, 4, Ireland. mjmckenn@iol.ie

Irish Journal of Medical Science

|April 10, 2012

Summary

Immunomodulator therapy (IMT) for multiple sclerosis (MS) may benefit spinal bone by reducing bone turnover. Further studies are needed to confirm IMT's effect on bone mineral density (BMD) and bone turnover markers (BTMs).

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Area of Science:

Neurology
Endocrinology
Rheumatology

Background:

The impact of immunomodulator therapy (IMT) on bone metabolism in multiple sclerosis (MS) patients remains unclear.
Understanding bone turnover in MS is crucial for managing potential complications.

Purpose of the Study:

To investigate the effects of IMT on bone turnover markers (BTMs) and bone mineral density (BMD) in patients with multiple sclerosis.

Main Methods:

A cohort of 29 MS patients on maintenance IMT underwent repeat BMD measurements over approximately 4 years.
Bone turnover markers (BTMs), including resorption and formation markers, were assessed at the time of repeat BMD measurements.

Main Results:

Spinal BMD remained stable, while hip BMD showed a decline.
Reduced levels of both bone resorption and formation markers were observed compared to normative values, suggesting an anti-resorptive effect of IMT.
Negative correlations were found between BTMs and changes in spinal BMD, but not hip BMD.

Conclusions:

IMT may exert a beneficial, anti-resorptive effect on spinal bone in MS patients.
Further prospective research is warranted to elucidate the long-term effects of IMT on BMD and bone turnover in MS.