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A Nonsequencing Approach for the Rapid Detection of RNA Editing
Published on: April 21, 2022
Accurate identification of human Alu and non-Alu RNA editing sites
Gokul Ramaswami1, Wei Lin, Robert Piskol
1Department of Genetics, Stanford University, California, USA.
Nature Methods
|April 10, 2012
Abstract:
We developed a computational framework to robustly identify RNA editing sites using transcriptome and genome deep-sequencing data from the same individual. As compared with previous methods, our approach identified a large number of Alu and non-Alu RNA editing sites with high specificity. We also found that editing of non-Alu sites appears to be dependent on nearby edited Alu sites, possibly through the locally formed double-stranded RNA structure.
