Related Experiment Video

Updated: May 23, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Percutaneous coronary intervention with bare metal stent vs. drug-eluting stent in hemodialysis patients

Hideki Ishii1, Takanobu Toriyama, Toru Aoyama

  • 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. hkishii@med.nagoya-u.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|April 10, 2012
PubMed

Insights

Drug-eluting stents (DES) show better long-term outcomes than bare metal stents (BMS) for patients on hemodialysis (HD) undergoing percutaneous coronary intervention (PCI). DES reduces major adverse cardiac events and target lesion revascularization beyond one year.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Nephrology

Background:

  • Coronary artery disease patients on hemodialysis (HD) face high restenosis rates after drug-eluting stent (DES) percutaneous coronary intervention (PCI).
  • Limited data exists on the long-term outcomes of DES in HD patients.

Purpose of the Study:

  • To compare the long-term clinical outcomes of DES versus bare metal stents (BMS) in HD patients undergoing PCI.
  • To evaluate the effectiveness of DES in reducing restenosis and major adverse cardiac events in this high-risk population.

Main Methods:

  • Retrospective comparison of 204 patients receiving BMS and 301 patients receiving DES for PCI.
  • Kaplan-Meier analysis to assess long-term clinical outcomes, including target lesion revascularization (TLR) and major adverse cardiac events (MACE).
  • Follow-up duration extended to 6 years for event rate analysis.

Main Results:

  • DES group showed significantly lower 6-year MACE rates (42.5%) compared to the BMS group (58.0%, P=0.036).
  • No significant difference in TLR at 1 year (17.8% vs. 21.3%, P=0.32).
  • Beyond 1 year, DES significantly reduced TLR rates compared to BMS (16.4% vs. 30.9%, P=0.019).

Conclusions:

  • DES implantation may be more effective than BMS for preventing medium to long-term TLR in HD patients.
  • While short-term restenosis after DES in HD patients is common, long-term benefits in reducing revascularization are evident.
Abstract

More Related Videos

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

Related Concept Videos

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...