Related Experiment Video
Updated: May 23, 2026

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients
Published on: July 14, 2023
Health-related quality of life and emotional problems in juvenile idiopathic arthritis
Dejan Stevanovic1, Gordana Susic
1Department of Psychiatry, General Hospital Sombor, Apatinski put 38, 25000, Sombor, Serbia. dejanstevanovic@eunet.rs
Insights
Depressive symptoms significantly impact health-related quality of life (HRQOL) in children with juvenile idiopathic arthritis (JIA). Screening for depression is crucial for comprehensive JIA care.
Area of Science:
- Pediatric Rheumatology
- Child Psychology
- Health Outcomes Research
Background:
- Children with juvenile idiopathic arthritis (JIA) face elevated risks for emotional difficulties.
- Health-related quality of life (HRQOL) is a critical outcome measure in pediatric chronic conditions.
Purpose of the Study:
- To investigate the association between depressive and anxiety symptoms and HRQOL in children with JIA.
- To identify which emotional symptoms most significantly predict HRQOL in this population.
Main Methods:
- Sixty-seven children with JIA and their parents participated.
- Anxiety symptoms were assessed using the Screen for Child Anxiety Related Emotional Disorders Questionnaire (SCARED).
- Depressive symptoms were measured by the Mood and Feeling Questionnaire (MFQ), and HRQOL by the Pediatric Quality of Life Inventory (PedsQL).
- Hierarchical multiple-regression analysis controlled for demographics, clinical factors, and pain.
Main Results:
- The regression model explained 63% of the variance in children's PedsQL scores and 49% in parents' scores.
- Depressive symptoms (MFQ scores) were significant predictors of HRQOL.
- Anxiety symptoms (SCARED scores) did not significantly contribute to the variance in HRQOL.
Conclusions:
- Depressive symptoms, not anxiety, substantially accounted for variability in HRQOL among children with JIA.
- Routine screening for depression should be integrated into the multimodal assessment and treatment of JIA.
Purpose:
Children with juvenile idiopathic arthritis (JIA) are at an increased risk of developing emotional problems. This study evaluated the associations between levels of depressive and anxiety symptoms and health-related quality of life (HRQOL) in these children.
Methods:
Sixty-seven children with JIA, together with one parent, participated. Anxiety symptoms were identified using the Screen for Child Anxiety Related Emotional Disorders Questionnaire (SCARED), while depressive symptoms were identified using the Mood and Feeling Questionnaire (MFQ). The Pediatric Quality of Life Inventory (PedsQL) was used for HRQOL assessments. Using hierarchical multiple-regression analysis, demographics, clinical factors, and pain were control variables, while anxiety (the SCARED score) and depressive symptoms (the MFQ score) were HRQOL (the PedsQL score) predictors.
Results:
The regression model emerged with specified variables explaining 63 % of the variance in the PedsQL score (F = 11.92, p < 0.01) among children. Among parents, the same set of variables accounted for 49 % the variance (F = 6.99, p < 0.01). The MFQ score, but not the SCARED, added most to the variance.
Conclusions:
Depressive symptoms, but not anxiety, accounted for substantial variability in levels of HRQOL when considered with demographics, clinical factors, and pain. Thus, screening for depression needs to be considered as a part of multimodal assessment and treatment approaches in JIA.
Related Concept Videos
Asthma-III: Symptoms and Complications
Classification of Asthma
Factors Affecting Illness
For instance, risk factors are connected to illness, disability,...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Rheumatic Heart Disease I: Introduction
Asthma III: Clinical Manifestations
