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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
[Oxidative stress in kidney disease patients]
J Vostálová1, A Galandáková, P Strebl
1ústav Lékarské Chemie a Biochemie Lékarské Fakulty UP Olomouc, Prednostka prof. RNDr. Jitka Ulrichová, CSc.
Abstract:
Patients with chronic kidney disease are exposed to oxidative stress (OS) that contributes to deterioration of health. Decrease in renal excretory capacity contributes to the accumulation of pro-oxidative substances that are detrimental not only to kidney but to the whole organism including the cardiovascular system. Components of antioxidant system play an important role in the elimination of the OS. The monitoring of antioxidant levels and products of oxidative damage in these patients and the correct interpretation of relationship between these markers and the function of kidney and other organs may contribute to the more effective treatment and health improvement of the patients.
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