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Meticillin-resistant Staphylococcus pseudintermedius: clinical challenge and treatment options
Linda A Frank1, Anette Loeffler
1Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN 37996, USA.
Veterinary Dermatology
|April 11, 2012
Summary
Meticillin-resistant Staphylococcus pseudintermedius (MRSP) poses a significant challenge in veterinary medicine. Effective treatment requires careful antimicrobial selection and comprehensive infection control to prevent spread.
Area of Science:
- Veterinary Dermatology
- Antimicrobial Resistance
- Zoonotic Pathogens
Background:
- Meticillin-resistant Staphylococcus pseudintermedius (MRSP) is a growing concern in small animal veterinary medicine.
- MRSP infections, particularly skin diseases, present therapeutic challenges due to widespread antimicrobial resistance.
Purpose of the Study:
- To review the clinical aspects of MRSP infections in small animals.
- To discuss current treatment options and infection control strategies for MRSP.
- To explore the implications of MRSP for animal health, public health, and the environment.
Main Methods:
- Literature review focusing on clinical cases and in vitro susceptibility data of MRSP.
- Analysis of treatment outcomes and adverse effects of various antimicrobial agents.
- Evaluation of infection control measures and zoonotic potential.
Main Results:
- MRSP is not more virulent than susceptible strains but infections may take longer to resolve.
- In vitro testing shows resistance to many common veterinary antimicrobials.
- Effective systemic options may include chloramphenicol, rifampicin, amikacin, clindamycin, and minocycline, though adverse effects can be limiting.
- Topical therapies can be effective in some cases.
Conclusions:
- Comprehensive management, including awareness and infection control, is crucial for treating MRSP infections.
- Veterinary practitioners need to carefully select antimicrobials based on susceptibility testing.
- Preventing the spread of this zoonotic pathogen is essential in veterinary settings and the community.
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