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Concurrent protracted febrile myalgia syndrome in a child with diabetic ketoacidosis

Korcan Demir1, Kürşat B Carman, Belde Kasap

  • 1Division of Pediatric Endocrinology, Children's Hospital, Gaziantep, Turkey. korcandemir@gmail.com

Pediatric Diabetes
|April 11, 2012
PubMed

Insights

Familial Mediterranean Fever (FMF) and its associated vasculitis, protracted febrile myalgia syndrome (PFMS), were diagnosed in a patient presenting with new-onset type 1 diabetes mellitus and diabetic ketoacidosis (DKA). Cytokine release from DKA may trigger FMF-associated PFMS.

Area of Science:

  • Genetics and Immunology
  • Endocrinology
  • Rheumatology

Background:

  • Familial Mediterranean Fever (FMF) is an autoinflammatory disease caused by MEFV gene mutations, leading to pyrin dysfunction and recurrent inflammation.
  • Protracted Febrile Myalgia Syndrome (PFMS) is a vasculitic manifestation linked to the MEFV M694V mutation, often requiring corticosteroid therapy.

Observation:

  • A case report details a patient diagnosed with FMF-associated PFMS concurrently with new-onset type 1 diabetes mellitus and diabetic ketoacidosis (DKA).
  • The patient's PFMS diagnosis occurred during the management of DKA, highlighting a potential temporal link.

Findings:

  • The study suggests that cytokine release associated with DKA might act as a trigger or predisposing factor for FMF-associated PFMS.
  • This observation points to a potential interplay between metabolic and autoinflammatory conditions.

Implications:

  • Understanding this association may improve diagnostic approaches for FMF in patients with DKA.
  • Further research into the immunomodulatory effects of DKA could elucidate shared pathogenic mechanisms with autoinflammatory diseases like FMF.

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