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Effect of marbofloxacin on Haemophilus parasuis nasal carriage

Carles Vilalta1, Nuria Galofré, Virginia Aragon

  • 1Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus Univ. Autònoma de Barcelona, Bellaterra, Barcelona, Spain.

Veterinary Microbiology
|April 11, 2012
PubMed

Insights

Marbofloxacin significantly reduces nasal carriage of Haemophilus parasuis in swine. However, the antibiotic

Area of Science:

  • Veterinary Microbiology
  • Animal Health
  • Antimicrobial Resistance

Background:

  • Haemophilus parasuis is a key respiratory tract colonizer and causes Glässer's disease in swine.
  • Understanding the efficacy of antimicrobials like marbofloxacin against H. parasuis nasal carriage is crucial for disease control.

Purpose of the Study:

  • To evaluate the impact of different marbofloxacin treatment regimens on the nasal carriage of H. parasuis in piglets.
  • To assess the duration of the antimicrobial effect and potential development of resistance.

Main Methods:

  • Three marbofloxacin treatment protocols were administered to piglets: 2mg/kg every 24h, 4mg/kg every 48h, and a single 8mg/kg dose.
  • Nasal carriage of H. parasuis was monitored and compared to control groups.
  • A longitudinal study on a farm with clinical Glässer's disease investigated the 8mg/kg dose's effect.

Main Results:

  • All marbofloxacin treatments significantly reduced H. parasuis nasal carriage compared to controls (p<0.05).
  • The highest dose (8mg/kg) resulted in no detectable H. parasuis in nasal cavities immediately post-treatment.
  • A significant reduction in nasal carriage was observed in the first week post-treatment, but diverse strains reappeared after 7 days.

Conclusions:

  • Marbofloxacin is effective in reducing H. parasuis nasal carriage in swine, with higher doses showing more immediate impact.
  • The antimicrobial effect appears transient, with bacterial strains re-emerging after treatment cessation.
  • No clear correlation was found between MICs, virulence, and treatment outcomes, suggesting complex dynamics in carriage.

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