Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 23, 2026

Porcine As a Training Module for Head and Neck Microvascular Reconstruction
07:43

Porcine As a Training Module for Head and Neck Microvascular Reconstruction

Published on: September 29, 2018

Second free flaps in head and neck reconstruction.

Gary Ross1, Tuija M Yla-Kotola, David Goldstein

  • 1Division of Plastic & Reconstructive Surgery, University Health Network, 200 Elizabeth Street, 8N-865, Toronto, ON M5G 2C4, Canada.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|April 11, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exceptional Response to Durvalumab and Tremelimumab in Pancreatic Acinar Cell Carcinoma With Ultramutated Phenotype Associated With a DNA Polymerase-ε Mutation.

JCO precision oncology·2026
Same author

Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target.

Cell reports. Medicine·2026
Same author

Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 mutant mice.

JCI insight·2026
Same author

Dose-dependent neurotoxic chemotherapy and corneal nerve morphological changes.

Clinical & experimental optometry·2026
Same author

<u>B</u>uccal fat applied to trans<u>o</u>ral robotic <u>l</u>ateral oropharyngectomy defects to lessen radical <u>t</u>onsillectomy pain (BOLT): a single-centre, phase II, parallel, randomised control trial study protocol.

BMJ open·2025
Same author

Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.

Journal of gastrointestinal oncology·2025

Second free flap reconstruction for head and neck cancer is often necessary. While successful, outcomes are significantly lower when the initial free flap failed, highlighting the importance of primary reconstruction success.

Area of Science:

  • Head and Neck Surgery
  • Reconstructive Surgery
  • Oncology

Background:

  • Ablative surgery for head and neck cancer frequently leads to defects requiring free flap reconstruction.
  • Advances in oncologic and adjuvant techniques have increased the incidence of patients needing a second free flap reconstruction.
  • This study evaluates outcomes of second free flap reconstructions in head and neck cancer patients.

Purpose of the Study:

  • To assess the outcomes of second free flap reconstructions in head and neck cancer patients.
  • To compare success rates between second free flaps for complications versus primary failure.
  • To identify factors influencing the success of repeat free flap procedures.

Main Methods:

  • A retrospective review of 1475 head and neck reconstructive surgeries over 17 years.

More Related Videos

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction
06:32

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Published on: December 5, 2025

Related Experiment Videos

Last Updated: May 23, 2026

Porcine As a Training Module for Head and Neck Microvascular Reconstruction
07:43

Porcine As a Training Module for Head and Neck Microvascular Reconstruction

Published on: September 29, 2018

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction
06:32

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Published on: December 5, 2025

  • Analysis of 123 patients who underwent a second free flap reconstruction.
  • Group 1 (n=93): second flap for tumor recurrence, second primary, or complications; Group 2 (n=30): second flap after primary flap failure.

    • Main Results:

    • Second free flap success rate was 96% (86/90) in Group 1 versus 73% (22/30) in Group 2 (p < 0.05).
    • Partial flap necrosis occurred in 4% of Group 1 patients and 3% of Group 2 patients (p > 0.05).
    • Success rates were significantly lower in patients with initial free flap failure.

    Conclusions:

    • Second free flaps are viable options for head and neck defects due to recurrence, second primaries, or complications.
    • The success rate of second free flaps is significantly compromised in cases of initial free flap failure.
    • Optimizing primary free flap success is crucial to avoid poorer outcomes with subsequent reconstructions.