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Related Experiment Video

Updated: May 23, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

IgG4-related kidney disease.

Lynn D Cornell¹

¹Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA. cornell.lynn@mayo.edu

Current Opinion in Nephrology and Hypertension

|April 11, 2012

Summary

Immunoglobulin G4-related disease (IgG4-RD) can affect the kidneys, causing tubulointerstitial nephritis (TIN) or membranous glomerulonephritis (MGN). Consider IgG4-RD in patients with these kidney conditions.

Area of Science:

Nephrology
Rheumatology
Immunology

Background:

Immunoglobulin G4-related disease (IgG4-RD) is an emerging systemic autoimmune condition.
Renal involvement is a recognized, albeit complex, manifestation of IgG4-RD.
Recent literature highlights various renal presentations of IgG4-RD.

Purpose of the Study:

To review the diverse renal manifestations of IgG4-related disease.
To delineate the clinical, laboratory, and pathological features of IgG4-related tubulointerstitial nephritis (TIN).
To discuss the growing recognition of glomerular disease in IgG4-RD.

Main Methods:

Review of recent literature on IgG4-related disease and renal involvement.
Analysis of clinical series and biopsy-proven cases of IgG4-related TIN.

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Inclusion of findings from the first international conference on IgG4-RD.

Main Results:

IgG4-related tubulointerstitial nephritis (TIN) is an accepted manifestation, presenting with mass lesions or renal failure.
Recent studies have further defined the features and diagnostic criteria for IgG4-related TIN.
Membranous glomerulonephritis (MGN) is increasingly recognized as a glomerular manifestation of IgG4-RD.

Conclusions:

IgG4-related disease should be considered in the differential diagnosis of TIN and MGN.
The precise role of the IgG4 antibody in disease pathogenesis remains an area for further investigation.