Related Experiment Video
Updated: May 23, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Psychopathology and special education enrollment in children with prenatal cocaine exposure
Todd P Levine1, Barry Lester, Linda Lagasse
1Department of Psychiatry, Alpert Brown Medical School and Women and Infants Hospital, Providence, RI 02905, USA. TLevine@wihri.org
Insights
Prenatal cocaine exposure (PCE) and child psychopathology significantly increase the likelihood of 11-year-olds needing special education services, including individualized education plans (IEPs). This highlights critical early-life risk factors for educational support.
Area of Science:
- Neuroscience
- Developmental Psychology
- Public Health
Background:
- Prenatal cocaine exposure (PCE) is a significant concern with potential long-term developmental impacts.
- Understanding factors influencing special education enrollment is crucial for early intervention.
- Individualized Education Plans (IEPs) are key services for children with special needs.
Purpose of the Study:
- To investigate the relationship between prenatal cocaine exposure (PCE) and enrollment in special education services among 11-year-old children.
- To examine the role of psychopathology and other risk factors in predicting IEP enrollment.
- To analyze the combined and independent effects of PCE and psychopathology on special education outcomes.
Main Methods:
- Prospective, longitudinal, multisite study of 498 children from The Maternal Lifestyle Study.
- Logistic regression analysis to assess the impact of PCE and psychopathology on IEP enrollment.
- Inclusion of environmental, maternal, and infant medical variables as covariates.
Main Results:
- Prenatal cocaine exposure (PCE) was a significant predictor of IEP enrollment.
- Child psychopathology, including oppositional defiant disorder and ADHD, also predicted IEP enrollment.
- Other significant factors included male gender, low birth weight, caregiver changes, low socioeconomic status, and caregiver depression.
Conclusions:
- PCE independently increases the likelihood of receiving an IEP.
- Psychopathology is a significant predictor of special education needs, both with and without PCE.
- These findings underscore the importance of addressing prenatal exposures and child mental health for educational support.
Objective:
This study evaluated how enrollment in special education services in 11-year-old children relates to prenatal cocaine exposure (PCE), psychopathology, and other risk factors.
Methods:
Participants were 498 children enrolled in The Maternal Lifestyle Study, a prospective, longitudinal, multisite study examining outcomes of children with PCE. Logistic regression was used to examine the effect of PCE and psychopathology on enrollment in an individualized education plan (IEP; a designation specific to children with special education needs), with environmental, maternal, and infant medical variables as covariates.
Results:
PCE, an interaction of PCE and oppositional defiant disorder, child attention-deficit hyperactivity disorder, parent-reported internalizing behaviors, and teacher-reported externalizing behaviors, predicted enrollment in an IEP. Other statistically significant variables in the model were male gender, low birth weight, being small for gestational age, white race, caregiver change, low socioeconomic status, low child intelligence quotient, caregiver depression, and prenatal marijuana exposure.
Conclusions:
PCE increased the likelihood of receiving an IEP with adjustment for covariates. Psychopathology also predicted this special education outcome, in combination with and independent of prenatal cocaine exposure.
Related Concept Videos
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Conduct Disorder
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

