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Increased mean platelet volume in cervicocephalic artery dissections.
O Kamisli1, S Kamisli, S Gonullu
1Department of Neurology, Inonu University Turgut Ozal Medical Center, Malatya, Turkey. okamisli@yahoo.com
Irish Journal of Medical Science
|April 11, 2012
Summary
Increased mean platelet volume (MPV) is linked to cervicocephalic artery dissections, particularly vertebral artery dissections. This finding suggests platelet reactivity plays a key role in the development of these conditions.
Area of Science:
- Vascular Medicine
- Hematology
- Neurology
Background:
- Cervicocephalic artery dissections are a significant cause of stroke.
- The role of platelets in the pathogenesis of these dissections requires further elucidation.
Purpose of the Study:
- To investigate the association between platelet parameters, specifically mean platelet volume (MPV) and platelet count, and cervicocephalic artery dissections.
- To compare these parameters between patients with dissections and healthy controls.
Main Methods:
- A case-control study involving 34 patients with cervicocephalic artery dissections (subdivided into vertebral and carotid artery dissections) and 30 control subjects.
- Measurement and comparison of platelet count and MPV between the dissection groups and the control group.
Main Results:
- Significantly higher MPV values were observed in the overall cervicocephalic artery dissection group compared to controls (p < 0.05).
- Specifically, the vertebral artery dissection subgroup exhibited significantly elevated MPV compared to controls.
- No significant difference in total platelet count was found between dissection groups and controls.
Conclusions:
- Elevated MPV may serve as an indicator of platelet activation and a potential risk factor for dissection-related stroke.
- Platelet reactivity appears to be crucial in the pathogenesis of cervicocephalic artery dissections, with a notable association in vertebral artery dissections.
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