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MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer

Bríd M Ryan1, Kara M Calhoun, Sharon R Pine

  • 1Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA.

International Journal of Cancer
|April 11, 2012
PubMed

Insights

Single Nucleotide Polymorphism 285 (SNP285) does not influence lung cancer risk or survival, contrary to findings in other cancers. This study indicates SNP285

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Conflicting reports exist on the role of MDM2 SNP309 in cancer risk.
  • SNP285 has been identified as an antagonist to SNP309, modulating SP1-mediated transcription.
  • SNP285 has been shown to influence the association between SNP309 and the risk of breast, ovarian, and endometrial cancers.

Purpose of the Study:

  • To investigate whether SNP285 confounds the effect of SNP309 on lung cancer risk and survival.
  • To assess the association of SNP309 and SNP285 with lung cancer in a multi-ethnic cohort.

Main Methods:

  • A cohort study was conducted with 720 controls and 556 lung cancer cases.
  • The study included both Caucasian and African American participants.
  • Genotyping was performed for SNP309 and SNP285.

Main Results:

  • Neither SNP309 nor SNP285 was significantly associated with lung cancer risk or survival.
  • Excluding individuals with the SNP285 variant C allele did not alter the SNP309-lung cancer association.
  • The findings suggest SNP285's effect may be specific to cancers in women.

Conclusions:

  • SNP285 does not appear to play a role in lung cancer risk or survival.
  • The antagonistic effect of SNP285 on SNP309 observed in other cancers is not replicated in lung cancer.
  • The influence of SNP285 may be limited to specific cancer types, particularly those affecting women.

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