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Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
Published on: December 27, 2024
Surgical management of metastatic spinal tumors
I Laufer1, D M Sciubba, M Madera
1Department of Neurological Surgery, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD 21287, USA.
Background:
The spine is the most common site of skeletal metastases. The evolution of surgical methods, medical treatment, and radiation therapy has led to improved survival, functional status, and quality of life for patients with cancer. The role of surgery in the treatment of patients with spinal metastases has evolved over time.
Methods:
A review of publications describing the role of open surgery and vertebroplasty was performed and the results are summarized.
Results:
The treatment goals of spinal metastases include the preservation and restoration of neurologic function and spinal stability. Modern imaging modalities provide accurate methods of tumor diagnosis. A variety of approaches and stabilization techniques are available and should be tailored to the location of the tumor and systemic comorbidities.
Conclusions:
As part of multidisciplinary treatment that includes radiation therapy and chemotherapy, surgery provides an effective method of restoration and preservation of neurologic function and spinal stability for patients with metastatic spinal tumors.