Related Experiment Video
Updated: May 23, 2026

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
Published on: June 2, 2022
Preoperative evaluation, premedication, and induction of anesthesia in infants and children
1Department of Anesthesiology and Perioperative Care, University of California, Irvine, Orange, California 92868, USA. sstrom@uci.edu
Insights
Nonpharmacologic methods effectively reduce pediatric perioperative anxiety, similar to sedative medications. Further research is needed to compare specific premedications and nonpharmacologic interventions for optimal outcomes.
Area of Science:
- Pediatric Anesthesiology
- Perioperative Medicine
- Evidence-Based Practice
Background:
- Anesthesia preparation and induction in children have seen significant advancements.
- Focus on reducing perioperative anxiety using nonpharmacologic and pharmacologic strategies.
Purpose of the Study:
- To review current techniques for reducing anxiety in pediatric anesthesia.
- To analyze recent large population studies and meta-analyses on these techniques.
Main Methods:
- Review of recent large population studies and meta-analyses.
- Evaluation of nonpharmacologic and pharmacologic anxiety reduction methods.
Main Results:
- Nonpharmacologic methods show effectiveness comparable to sedative premedications, except for parent-present induction.
- Healthcare providers can be trained to enhance anxiety-reducing behaviors.
- Clonidine and dexmedetomidine demonstrate qualities similar to or better than midazolam.
Conclusions:
- Further large-scale studies are required for nonpharmacologic interventions like parental acupuncture.
- More research is needed on specific outcomes (onset, emergence, discharge, postoperative nausea/vomiting, delirium) to differentiate sedative premedications.
Purpose Of Review:
Preparation for and induction of anesthesia in children has evolved significantly over the last decade, with particular reference to the reduction of perioperative anxiety reduction by nonpharmacologic and pharmacologic means. Several new large population studies and meta-analyses further scrutinize the current techniques.
Recent Findings:
Many nonpharmacologic methods to reduce anxiety are effective λU similar to sedative premedications, with the exception of parent present induction of anesthesia. Healthcare providers can be taught to increase anxiety-reducing behaviors through an educational intervention. Clonidine and dexmedetomidine have many similar or superior qualities to midazolam.
Summary:
Larger studies still need to be conducted before wide-scale application of many nonpharmalogical interventions such as parental acupuncture. Similarly, more investigation should be done on outcomes such as onset, emergence, and discharge times, as well as the postoperative response with reference to emergence delirium and postoperative nausea and vomiting prevention to outline the differences among sedative premedications such as midazolam, clonidine, and dexmedetomidine.
Related Concept Videos
Drug Dosing: Infants and Children
Parenteral Anesthetics: Overview
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Factors Affecting Drug Response: Overview
Stages of General Anesthesia
Pharmacokinetics in Pediatric Patients: Drug Excretion
