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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Lipoprotein(a), interleukin-10, C-reactive protein, and 8-year outcome after percutaneous coronary intervention

Isabella Kardys1, Rohit M Oemrawsingh, I Patrick Kay

  • 1Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. i.kardys@erasmusmc.nl

Clinical Cardiology
|April 11, 2012
PubMed

Insights

Pre-procedure Lipoprotein(a) (Lp[a]) predicts short-term cardiac events after percutaneous coronary intervention (PCI). High-sensitivity C-reactive protein (CRP) predicts long-term events in complex PCI patients.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Interventional Cardiology

Background:

  • Complex percutaneous coronary intervention (PCI) carries risks of major adverse cardiac events (MACE).
  • Identifying preprocedural biomarkers can improve risk stratification in patients undergoing PCI.

Purpose of the Study:

  • To investigate the association between preprocedural biomarker levels (Lipoprotein(a) [Lp(a)], interleukin-10 [IL-10], and high-sensitivity C-reactive protein [CRP]) and incident MACE in complex PCI patients.
  • To evaluate the short-term and long-term prognostic value of these biomarkers.

Main Methods:

  • Prospective study of 161 patients undergoing PCI with sirolimus-eluting stenting.
  • Preprocedural blood samples measured Lp(a), IL-10, and CRP levels.
  • Patients followed for MACE (death, myocardial infarction, repeat revascularization) at 1 year and long-term (median 6 years) using Cox proportional hazard models.

Main Results:

  • Lipoprotein(a) (Lp[a]) was associated with increased 1-year MACE risk (HR 3.1), but this significance diminished long-term.
  • Interleukin-10 (IL-10) showed a trend towards association with MACE at both 1-year (HR 2.1) and long-term follow-up.
  • High-sensitivity C-reactive protein (CRP) was not significantly associated with 1-year MACE but predicted long-term MACE risk (HR 1.9).

Conclusions:

  • Preprocedural Lp(a) levels are associated with short-term prognosis following PCI.
  • Preprocedural CRP levels are associated with long-term prognosis following PCI in complex patients.
Abstract

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