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Updated: May 23, 2026

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
07:48

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Published on: June 8, 2019

Limb blood flow after class 4 laser therapy.

Kelly A Larkin1, Jeffrey S Martin, Elizabeth H Zeanah

  • 1Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118205, Gainesville, FL 32611, USA. klarkin@hhp.ufl.edu

Journal of Athletic Training
|April 11, 2012
PubMed
Summary

Low-level laser therapy (LLLT) at 3-W significantly increased forearm blood flow in healthy men. This finding suggests LLLT may be a viable therapeutic option for enhancing circulation and promoting tissue healing.

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Area of Science:

  • Biomedical Engineering
  • Physiology
  • Therapeutic Modalities

Background:

  • Laser therapy is proposed to enhance soft tissue circulation.
  • Improved blood flow can aid healing by mitigating ischemia, hypoxia, and edema.
  • Quantifying laser therapy's circulatory effects is crucial for therapeutic application.

Purpose of the Study:

  • To establish an effective therapeutic dose range for laser therapy in augmenting forearm blood flow.
  • To investigate the dose-dependent effects of laser therapy on circulation.

Main Methods:

  • A crossover study design was employed in a controlled laboratory setting.
  • Ten healthy young men received four doses of Class 4 laser therapy (sham, 1 W, 3 W, 6 W) to the biceps brachii.
  • Blood flow was measured using venous occlusion plethysmography, with repeated-measures ANOVA analyzing changes at various time points.

Main Results:

  • The 3-W laser therapy dose significantly increased forearm blood flow compared to baseline.
  • Peak increases in blood flow were observed during and immediately after the 3-W treatment.
  • Sham, 1-W, and 6-W doses did not produce significant changes in blood flow.

Conclusions:

  • A 3-W (360-J) dose of laser therapy effectively enhances blood flow in soft tissues.
  • This specific dose demonstrates potential as a therapeutic modality for improving circulation.