Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preanaesthetic medication with clonidine.

P M Wright1, U A Carabine, S McClune

  • 1Department of Anaesthetics, Queen's University of Belfast.

British Journal of Anaesthesia
|November 1, 1990
PubMed
Summary

Oral clonidine at 0.3 mg effectively reduced anxiety and sedation in patients undergoing surgery. However, it commonly caused hypotension, urging caution in its use as a premedicant.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hereditary non-polyposis colorectal cancer syndrome.

The Australian and New Zealand journal of surgery·1999
Same author

Work production and work absorption in muscle strips from vertebrate cardiac and insect flight muscle fibers.

Advances in experimental medicine and biology·1999
Same author

Do gastrointestinal symptoms vary with the menstrual cycle?

British journal of obstetrics and gynaecology·1999
Same author

Hoof size, shape, and balance as possible risk factors for catastrophic musculoskeletal injury of Thoroughbred racehorses.

American journal of veterinary research·1998
Same author

The usefulness of CD64, other monocyte-associated antigens, and CD45 gating in the subclassification of acute myeloid leukemias with monocytic differentiation.

American journal of clinical pathology·1998
Same author

An investigation into the effects of sodium citrate ingestion on high-intensity exercise performance.

International journal of sport nutrition·1998

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Premedication aims to reduce patient anxiety and improve anesthetic induction.
  • Oral clonidine has shown potential anxiolytic and sedative properties.

Purpose of the Study:

  • To assess the efficacy and safety of oral clonidine (0.3 mg) as a routine premedicant in female patients.

Main Methods:

  • A randomized, double-blind, placebo-controlled study involving 69 normotensive female patients.
  • Comparison of oral clonidine 0.3 mg against an inert placebo as a premedicant.

Main Results:

  • Clonidine significantly reduced anxiety and sedation (P<0.05).
  • It decreased the required dose of methohexitone for sleep induction (P<0.05).
  • Clonidine attenuated the heart rate increase post-intubation (P<0.05) but did not affect the blood pressure increase.

Conclusions:

  • Oral clonidine 0.3 mg demonstrates anxiolytic and sedative effects, reducing anesthetic requirements.
  • Common occurrences of intraoperative and postoperative hypotension necessitate caution when using clonidine as a premedicant.

Related Experiment Videos