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[Antimicrobial resistance in clinical patterns of Pseudomonas aeruginosa]

María del Mar Casal1, Manuel Causse, Fernando Rodríguez-López

  • 1Hospital Reina Sofía, Servicio de Microbiología y Parasitología, Avda Menéndez Pidal s/n, Córdoba, Spain.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|April 11, 2012
PubMed

Insights

Pseudomonas aeruginosa antibiotic resistance remained stable from 2005-2010, with increased susceptibility to certain drugs. Surveillance is crucial as intrahospital and extrahospital strains show differing resistance patterns.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Pseudomonas aeruginosa is a common cause of hospital-acquired infections.
  • This opportunistic pathogen exhibits significant natural and acquired resistance to antibiotics.
  • Understanding resistance patterns is vital for effective treatment.

Purpose of the Study:

  • To analyze antibiotic resistance trends of P. aeruginosa.
  • To compare resistance patterns in hospital-acquired versus community-acquired infections.
  • To assess antimicrobial susceptibility over a six-year period.

Main Methods:

  • Analysis of 3,029 P. aeruginosa isolates from clinical samples (2005-2010).
  • Utilized the WIDER I semiautomatic system for identification and susceptibility testing.
  • Applied MENSURA group criteria for susceptibility and resistance evaluation.

Main Results:

  • Overall P. aeruginosa antimicrobial susceptibility remained consistent between 2005 and 2010.
  • Increased susceptibility observed for amikacin, gentamicin, and cephalosporins.
  • Significant differences in susceptibility noted between intrahospital and extrahospital strains in 2010, except for tobramycin and fosfomycin.

Conclusions:

  • Periodic surveillance of P. aeruginosa susceptibility and resistance is essential.
  • Resistance patterns vary between different healthcare settings.
  • Extrapolating resistance data across regions or settings is not always advisable for therapeutic guidelines.

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