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[Infection and blood filterability].

G Ciuffetti1, G Lupattelli, R Lombardini

  • 1Istituto di II Clinica Medica, Università degli Studi di Perugia.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|April 1, 1990
PubMed
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Acute bacterial infections impair whole blood filterability, a measure of blood flow through filters. These impairments persist even after patients recover clinically, suggesting long-term effects on blood cell function.

Area of Science:

  • Hematology
  • Immunology
  • Infectious Diseases

Background:

  • Acute bacterial infections trigger inflammatory responses.
  • Blood rheology, including whole blood filterability, can be affected by infection and inflammation.

Purpose of the Study:

  • To assess changes in whole blood filterability during acute bacterial infections.
  • To determine if these changes persist after clinical recovery.

Main Methods:

  • Whole blood filterability was measured using a low shear positive pressure nuclepore filtration system.
  • Measurements were taken in 21 patients during acute infection and after 4 weeks of recovery.
  • Data were compared to 40 healthy controls.

Main Results:

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  • Patients with acute bacterial infections exhibited impaired whole blood filterability compared to healthy controls.
  • This impairment in filterability remained even after the patients had clinically recovered.

Conclusions:

  • Acute bacterial infections lead to persistent alterations in whole blood filterability.
  • These findings suggest potential long-term impacts on blood rheology following infection.