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[Serum osteocalcin in hyperthyroidism].

I Roiter1, P Legovini, G Da Rin

  • 1I Divisione Medica, Ospedale Regionale di Treviso.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|April 1, 1990
PubMed
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Hyperthyroidism accelerates bone turnover, increasing both bone resorption and formation. This study found elevated serum osteocalcin (sBGP) and alkaline phosphatase in hyperthyroid patients, indicating stimulated bone metabolism.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Biochemistry

Background:

  • Hyperthyroidism is associated with altered bone metabolism.
  • Increased serum osteocalcin (sBGP) has been observed in hyperthyroid patients.

Purpose of the Study:

  • To evaluate increased serum osteocalcin (sBGP) in hyperthyroidism.
  • To assess bone metabolism biochemical parameters in hyperthyroid patients.

Main Methods:

  • Measured serum calcium, phosphate, PTH, calcitonin, 25OH vitD, alkaline phosphatase, and thyroid hormones.
  • Assessed urinary calcium, hydroxyproline, and creatinine.
  • Compared 20 hyperthyroid patients with 20 age and sex-matched healthy controls.

Main Results:

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  • Significantly increased sBGP, serum calcium, and alkaline phosphatase in hyperthyroid patients.
  • Elevated urinary calcium and hydroxyproline excretion in hyperthyroid patients.
  • Significant correlation found between thyroid hormones and sBGP.

    • Conclusions:

    • Hyperthyroidism accelerates bone turnover, stimulating both osteoclastic bone resorption and osteoblastic bone formation.
    • Increased sBGP and alkaline phosphatase suggest enhanced osteoblastic activity.
    • Elevated calcium and hydroxyproline indicate increased osteoclastic activity.