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Updated: May 23, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Artificial electron carriers for photoenzymatic synthesis under visible light
Sahng Ha Lee1, Hye Jung Lee, Keehoon Won
1KAIST Institute for the BioCentury, Department of Materials Science and Engineering, Daejeon, Republic of Korea.
Abstract:
NAD analogues can be employed as artificial electron carriers for photoenzymatic synthesis under visible light. Four different NAD analogues that have a 3-substituted pyridine ring have been investigated. 3-Acetylpyridine adenine dinucleotide and 3-pyridinealdehyde adenine dinucleotide were photochemically reduced much more efficiently than NAD, while their reduced products showed coenzyme activity comparable to natural NAD.
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