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Published on: September 19, 2020
Structure-property investigations with dielectric study on phosphorylcholine-based polyurethane
1Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, People's Republic of China.
Journal of Biomedical Materials Research. Part A
|April 11, 2012
Summary
Researchers developed a new polyurethane biomaterial with phosphorylcholine for medical devices. This anticoagulant material shows promising mechanical and biological properties, with potential applications in blood-contacting applications.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Surface Chemistry
Background:
- Polyurethanes are widely used in medical devices.
- Developing anticoagulant biomaterials is crucial for preventing blood clots.
- Phosphorylcholine-based polymers offer potential for improved hemocompatibility.
Purpose of the Study:
- To synthesize and characterize a novel polyurethane with zwitterionic phosphorylcholine on the main chain.
- To evaluate the mechanical and biological properties of the synthesized polyurethane for medical device applications.
- To investigate the dielectric properties of the material in both dry and aqueous environments to understand its behavior and mechanism of biocompatibility.
Main Methods:
- Synthesis of phosphorylcholine-based polyurethane.
- Structural characterization using Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance ((1)H NMR).
- Mechanical testing (tensile strength, elastic modulus) and biological evaluation (platelet adhesion).
- Dielectric spectroscopy analysis of solid films and films in water.
Main Results:
- The synthesized polyurethane exhibited satisfactory mechanical and biological properties, meeting medical device requirements.
- Platelet adhesion was low, indicating anticoagulant potential.
- Dielectric dispersion in solid films revealed condensed ionic structures, enhancing rigidity and elastic modulus.
- Dielectric measurements in water provided insights into interface dynamics and surface properties.
Conclusions:
- The phosphorylcholine-based polyurethane demonstrates potential as an anticoagulant biomaterial for medical devices.
- The material's enhanced mechanical properties are linked to its ionic structures.
- A new hypothesis suggests hydrated surfaces of biomaterials can respond to electromagnetic stimuli, contributing to biocompatibility.
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