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Related Experiment Video

Updated: May 23, 2026

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

EnzyBase: a novel database for enzybiotic studies.

Hongyu Wu¹, Hairong Lu, Jinjiang Huang

¹State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.

BMC Microbiology

|April 12, 2012

Summary

This summary is machine-generated.

Enzybiotics show promise against drug-resistant bacteria. A new database, EnzyBase, consolidates enzybiotic information, aiding research and the development of new antimicrobial therapies to combat rising antibiotic resistance.

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Area of Science:

Biochemistry
Bioinformatics
Microbiology

Background:

Enzybiotics are emerging as alternatives to antibiotics for combating drug-resistant bacteria.
Limited characterization and data accessibility hinder enzybiotic research.
A centralized database is needed to streamline the study of these bioactive proteins.

Purpose of the Study:

To develop a comprehensive and user-friendly database for enzybiotics.
To facilitate efficient retrieval and analysis of enzybiotic data for researchers.
To support the discovery and design of novel enzybiotic-based therapies.

Main Methods:

Development of EnzyBase, a novel database containing 1144 enzybiotics from 216 natural sources.
Data curation from authoritative public databases and scientific literature to ensure quality.
Implementation of an intuitive interface for data retrieval and sequence homology searches (BLAST).

Main Results:

EnzyBase provides a centralized repository of enzybiotic information.
The database enables rapid data access and sequence analysis.
Examples of database-aided enzybiotic discovery and design are presented.

Conclusions:

EnzyBase is a unique resource for enzybiotic research.
The database supports in silico enzybiotic combination and novel enzybiotic design.
EnzyBase is a valuable platform for addressing the challenge of drug-resistant pathogens.