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Staphylococcus aureus infections in pediatric patients with diabetes mellitus

Erin N Menne1, Rona Yoffe Sonabend, Edward O Mason

  • 1Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.

The Journal of Infection
|April 12, 2012
PubMed

Insights

Children with diabetes mellitus (DM) experiencing Staphylococcus aureus infections often have poor glycemic control and recurrent infections. Improving blood sugar management may lower the risk and incidence of these serious bacterial infections.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Endocrinology

Background:

  • Staphylococcus aureus infections pose a significant health risk, particularly in vulnerable populations.
  • Children with diabetes mellitus (DM) may have altered susceptibility to infections.
  • Understanding the specific challenges of S. aureus infections in pediatric DM is crucial for effective management.

Purpose of the Study:

  • To characterize Staphylococcus aureus infections in children with diabetes mellitus.
  • To identify risk factors and clinical features associated with these infections.
  • To compare infection patterns in diabetic children to a non-diabetic control group.

Main Methods:

  • Retrospective review of a surveillance database for S. aureus infections in children with DM.
  • Molecular characterization of S. aureus isolates.
  • Comparison of cases (children with DM and S. aureus infection) to age-matched controls using conditional logistic regression.

Main Results:

  • Forty-seven cases of S. aureus infection in children with DM were identified.
  • Poor glycemic control (HbA1c > 10%) was prevalent in cases.
  • Cases showed higher rates of recurrent infections and were more likely to be female compared to controls.
  • Methicillin-resistant S. aureus (MRSA) was common, particularly in recurrent infections.

Conclusions:

  • Children with DM and S. aureus infections frequently exhibit poor glycemic control and increased recurrence rates.
  • Female gender and recurrent infections were more common in the diabetic cohort.
  • Enhanced glycemic control in pediatric diabetes may mitigate the risk and burden of S. aureus infections.
Abstract

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