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Updated: May 23, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Ocular features of multiple endocrine neoplasia type 2b]
Zhi-qiao Zhang1, Xiao-wei Liu, Fang-tian Dong
1Department of Ophthalmology, Chinese Academy of Medical Sciences, Beijing, China.
Zhonghua Yi Xue Za Zhi
|April 12, 2012
Summary
Multiple endocrine neoplasia type 2b (MEN 2b) commonly presents with thickened corneal nerve fibers. Other ocular findings include nodules on the eyelids, conjunctiva, and iris.
Area of Science:
- Ophthalmology
- Endocrinology
- Genetics
Context:
- Multiple endocrine neoplasia type 2b (MEN 2b) is a rare genetic disorder.
- MEN 2b is characterized by medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas.
Purpose:
- To investigate and document the ocular manifestations in patients diagnosed with MEN 2b.
Summary:
- Analysis of three MEN 2b cases revealed thickened corneal nerve fibers as a consistent finding.
- Additional ocular features observed included eyelid nodules, conjunctival nodules, and iris nodules.
Impact:
- Highlights thickened corneal nerve fibers as a key ocular sign for MEN 2b diagnosis.
- Contributes to understanding the spectrum of clinical features associated with MEN 2b.
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