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[Effects of extracorporeal cardiac shock wave therapy in patients with ischemic heart failure]
Yun-zhu Peng1, Tao Guo, Ping Yang
1Department of Cardiology, Kunming Medical College, Kunming, China.
Insights
Extracorporeal cardiac shock wave therapy (CSWT) improved symptoms, cardiac function, and exercise tolerance in patients with ischemic heart failure. This non-invasive treatment offers a safe and effective option for managing this condition.
Area of Science:
- Cardiology
- Regenerative Medicine
- Medical Devices
Context:
- Ischemic heart failure (IHF) significantly impacts patient quality of life and prognosis.
- Current treatment options for IHF have limitations in improving cardiac function and exercise capacity.
- Non-invasive therapeutic modalities are sought to enhance treatment strategies for IHF.
Purpose:
- To assess the feasibility, safety, and efficacy of extracorporeal cardiac shock wave therapy (CSWT) in patients diagnosed with ischemic heart failure.
- To evaluate the impact of CSWT on clinical symptoms, cardiac function, and exercise tolerance in IHF patients.
Summary:
- Fifty IHF patients with left ventricular ejection fraction (LVEF) < 50% were randomized to CSWT or a control group.
- CSWT involved 9 sessions over 3 months, with myocardial viability assessed using SPECT.
- Improvements in NYHA class, CCS score, SAQ, 6 MWT, LVEF, LVEDD, and reduced nitroglycerin use were observed in the CSWT group at 1 month.
Impact:
- CSWT demonstrated significant improvements in symptom burden, quality of life, and exercise tolerance in IHF patients.
- The therapy proved to be a safe and feasible non-invasive option, with no procedural complications reported.
- CSWT emerged as an independent factor for enhanced cardiac function and echocardiographic parameters, suggesting its potential as a novel therapeutic approach.
Objective:
To evaluate the feasibility, safety and efficiency of extracorporeal cardiac shock wave therapy (CSWT) in patients with ischemic heart failure.
Methods:
Fifty patients with ischemic heart failure and left ventricular ejection fraction (LVEF) < 50% were randomized to CSWT (shots/spot at 0.09 mJ/mm(2) for 9 spots, 9 times within 3 month) or control group. Dual isotope simultaneous acquisition single-photon emission computed tomography with (99)Tc(m)-sestamibi/(18)F-fluorodeoxyglucose ((99)Tc(m)-MIBI/(18)F-FDG) was performed before randomization and at 1 month after CSWT/control to locate and evaluate viable myocardium region. Canadian cardiovascular society (CCS) class sores, NYHA, Seattle Angina Questionnaire (SAQ), 6-min walk test (6 MWT), left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD) and the dosage of nitroglycerin use were compared between two groups at each time point.
Results:
All patients completed the study protocol without procedural complications. At 1 month, patients in CSWT group experienced improvement in NYHA (P < 0.01), CCS (P < 0.01), SAQ (P = 0.021), 6 MWT (P = 0.012) and dosage of nitroglycerin use (P < 0.01) compared to baseline. LVEF [45.0 (39.0, 48.0) vs. 47.0 (42.0, 50.0) P = 0.001], LVEDD [58.0 (56.0, 59.0) vs. 56.0 (55.0, 58.0) P = 0.002], summed perfused score [23.0 (20.5, 24.5) vs. 20.0 (18.0, 22.0) P < 0.01] and metabolic score [25.0 (23.0, 26.0) vs. 24.0 (21.5, 25.0) P = 0.028] were also improved in CSWT group. All these parameters remained unchanged in control group between baseline and at 1 month. CSWT was independent factor for improved cardiac function, quality of life and echocardiography parameters after adjusting for known factors which might affect outcome.
Conclusion:
CSWT could improve symptom, cardiac function, quality of life and exercise tolerance in patients with ischemic heart failure, CSWT might serve as a new, non-invasive, safe and efficient therapy for these patients.
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