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Published on: August 9, 2024
[The value of SYNTAX score in predicting outcome patients undergoing percutaneous coronary intervention]
Yue-chun Gao1, Xian-peng Yu, Ji-qiang He
1Department of Cardiology, Capital Medical University, Beijing , China.
Insights
The SYNTAX score effectively predicts major adverse cardiac and cerebrovascular events (MACCE) in patients with complex coronary artery disease undergoing percutaneous coronary intervention. Both the standard and clinical SYNTAX scores showed predictive value, with no significant difference between them.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Imaging & Diagnostics
Context:
- Complex coronary artery disease (three-vessel or left-main) poses significant risks.
- Percutaneous coronary intervention (PCI) is a common treatment strategy.
- Accurate risk stratification is crucial for optimal patient management.
Purpose:
- To evaluate the predictive capability of the SYNTAX score for major adverse cardiac and cerebrovascular events (MACCE).
- To compare the predictive performance of the standard SYNTAX score versus the clinical SYNTAX score.
- To assess MACCE risk in patients with three-vessel or left-main coronary artery disease undergoing PCI.
Summary:
- A retrospective analysis of 190 patients undergoing PCI for complex coronary artery disease was performed.
- Both SYNTAX score and clinical SYNTAX score were independently associated with MACCE.
- MACCE rates increased significantly across tertiles of both SYNTAX and clinical SYNTAX scores, indicating their predictive value.
Impact:
- The SYNTAX score serves as a valuable tool for predicting adverse outcomes in patients with complex coronary artery disease undergoing PCI.
- Findings support the use of the SYNTAX score in clinical decision-making for PCI procedures.
- The study highlights the importance of pre-procedural risk assessment using anatomical complexity scores.
Objective:
To assess the value of SYNTAX score to predict major adverse cardiac and cerebrovascular events (MACCE) among patients with three-vessel or left-main coronary artery disease undergoing percutaneous coronary intervention.
Methods:
190 patients with three-vessel or left-main coronary artery disease undergoing percutaneous coronary intervention (PCI) with Cypher select drug-eluting stent were enrolled. SYNTAX score and clinical SYNTAX score were retrospectively calculated. Our clinical Endpoint focused on MACCE, a composite of death, nonfatal myocardial infarction (MI), stroke and repeat revascularization. The value of SYNTAX score and clinical SYNTAX score to predict MACCE were studied respectively.
Results:
29 patients were observed to suffer from MACCE, accounting 18.5% of the overall 190 patients. MACCE rates of low (≤ 20.5), intermediate (21.0 - 31.0), and high (≥ 31.5) tertiles according to SYNTAX score were 9.1%, 16.2% and 30.9% respectively. Both univariate and multivariate analysis showed that SYNTAX score was the independent predictor of MACCE. MACCE rates of low (≤ 19.5), intermediate (19.6 - 29.1), and high (≥ 29.2) tertiles according to clinical SYNTAX score were 14.9%, 9.8% and 30.6% respectively. Both univariate and multivariate analysis showed that clinical SYNTAX score was the independent predictor of MACCE. ROC analysis showed both SYNTAX score (AUC = 0.667, P = 0.004) and clinical SYNTAX score (AUC = 0.636, P = 0.020) had predictive value of MACCE. Clinical SYNTAX score failed to show better predictive ability than the SYNTAX score.
Conclusions:
Both SYNTAX score and clinical SYNTAX score could be independent risk predictors for MACCE among patients with three-vessel or left-main coronary artery disease undergoing percutaneous coronary intervention. Clinical SYNTAX score failed to show better predictive ability than the SYNTAX score in this group of patients.
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