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Updated: May 23, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

[Association of a high ankle brachial index with microvascular diseases of diabetes]

Xiang Li1, Hui Ren, Yu-zhen Wang

  • 1Department of Endocrinology, PLA Diabetes Center, PLA No. 306 Hospital, Beijing 100101, China.

Zhonghua Yi Xue Za Zhi
|April 12, 2012
PubMed

Insights

A high ankle-brachial index (ABI) in diabetics is linked to smoking and high blood pressure, not microvascular complications. This finding suggests a high ABI doesn't indicate worse diabetic disease progression.

Area of Science:

  • Cardiovascular Research
  • Diabetology
  • Vascular Medicine

Context:

  • The ankle-brachial index (ABI) is a key indicator of peripheral artery disease.
  • Understanding ABI variations in diabetic patients is crucial for assessing cardiovascular risk.
  • Microvascular complications significantly impact diabetic patient outcomes.

Purpose:

  • To investigate the relationship between a high ankle-brachial index (ABI) and diabetic microvascular diseases.
  • To compare the predictive strength of high ABI versus low ABI for these complications.
  • To identify factors associated with an elevated ABI in a diabetic population.

Summary:

  • This study analyzed ABI in 3293 diabetic patients, identifying 50 with high ABI (>1.3).
  • High ABI was significantly associated with smoking and elevated systolic blood pressure.
  • No association was found between high ABI and diabetic nephropathy, neuropathy, or retinopathy.

Impact:

  • The findings suggest that a high ABI in diabetics is primarily associated with traditional atherosclerotic risk factors, not advanced microvascular disease.
  • This research refines the interpretation of high ABI in diabetic individuals, potentially influencing risk stratification strategies.
  • Clinicians should consider smoking and blood pressure alongside ABI in diabetic patients to assess cardiovascular risk comprehensively.
Abstract

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