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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[The role of a workflow in diagnosing biliary causes for acute pancreatitis]
Luo Zuo1, Chun-hui Wang, Jin-lin Yang
1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
Objective:
To establish a practical and effective clinical pathway (CP) for the etiological diagnosis of acute biliary pancreatitis.
Methods:
A total of 2216 patients enrolled were randomly divided into control group (n = 1120) and CP group (n = 1096) according to different etiological diagnosis methods including following doctor's established experiences and habits and the designed CP in our study.
Results:
There was no significant difference in baseline data between the two groups. The etiology of acute pancreatitis was determined in 91.1% (999/1096) of cases in the CP group which was significantly higher than the control group (65.5%, 734/1120), P < 0.05. The enhanced etiological determination of CP group was mainly consisted of the increased detection of biliary stones, duodenal diseases as well as pancreas divisum, P < 0.05. The positive etiological determination of magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography in the CP group were 59.1% (273/462) and 86.0% (98/114), respectively.
Conclusions:
The CP established in this study significantly enhances the biliary etiological determination of acute pancreatitis. It is easy to be conducted and may be of importance to improve the quality of etiological diagnosis of acute pancreatitis.
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