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Updated: May 23, 2026
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
[A comparative analysis of three diagnostic criteria for multiple myeloma]
1Peking University People's Hospital, Institute of Hematology, Beijing, China.
Objective:
To compare the sensitivity among three diagnostic criteria for multiple myeloma.
Methods:
A total of 220 patients with multiple myeloma were studied retrospectively to compare the sensitivity, as well as their clinical manifestations, cell morphology in bone marrow and immunophenotype.
Results:
(1) The sensitivity of domestic diagnostic criterion in 1975 was 79.1% (174/220) and there were some drawbacks in type identify. The sensitivity of WHO diagnostic criterion in 2001 was 97.3% (214/220) and the sensitivity of domestic diagnostic criteria in 2011 was 100%. (2) Immunoglobulin level in 12.7% (28/220) patients was < 30 g/L, plasma cells count in bone marrow in 13.6% (30/220) was < 10%; 2.7% (6/220) patients had not met the standard in immunity globulin and bone marrow plasma cells count. (3) The immunophenotype was CD(38) positive (100%), restricted light chain (kappa/lambda) and CD(19)100%, CD(138) (98.2%, 216/220) negative.
Conclusions:
Among the three diagnostic criteria, the highest was 2011 domestic diagnostic criteria. Comprehensive analysis include clinical manifestations, cell morphology, immunophenotype will contribute to the diagnosis for multiple myeloma.
