Novel structural and functional insights into the MoxR family of AAA+ ATPases

Keith S Wong1, Walid A Houry

  • 1Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

Insights

MoxR ATPases, widespread in microbes, are newly found to modulate stress responses and aid protein complex maturation. Their unique AAA+ domain structure resembles magnesium chelatase, suggesting novel functions.

Area of Science:

  • Microbiology
  • Biochemistry
  • Structural Biology

Background:

  • MoxR family of ATPases are conserved in bacteria and archaea.
  • Cellular functions of MoxR ATPases are not well understood.
  • Proposed roles include chaperone-like functions and cofactor insertion.

Purpose of the Study:

  • To review newly identified functions of MoxR ATPases.
  • To present recent structural insights into MoxR proteins.
  • To explore the implications of MoxR structure for function.

Main Methods:

  • Literature review of recent studies on MoxR ATPases.
  • Analysis of structural data from X-ray crystallography or cryo-EM.
  • Comparative analysis with other AAA+ proteins and related complexes.

Main Results:

  • MoxR proteins modulate diverse stress responses (oxidative, acid, heat) and metabolic pathways (CO utilization).
  • Structural studies reveal unique AAA+ domain organization in MoxR proteins.
  • This organization is similar to the ATPase component of magnesium chelatase complexes.

Conclusions:

  • MoxR ATPases play critical roles in microbial stress adaptation and complex assembly.
  • The unique structure suggests a conserved or related mechanism of action.
  • Further research into MoxR function and structure is warranted.

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