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Updated: May 23, 2026
11:09
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Thiol-yne coupling: revisiting old concepts as a breakthrough for up-to-date applications
Alessandro Massi1, Daniele Nanni
1Dipartimento di Chimica, Università di Ferrara, Ferrara, Italy. alessandro.massi@unife.it
Organic & Biomolecular Chemistry
|April 12, 2012
Summary
Radical thiol-yne coupling (TYC) offers a metal-free, efficient alternative to other click chemistry reactions. This review highlights recent advancements in its application for materials chemistry and bioconjugation.
Area of Science:
- Chemical synthesis
- Click chemistry
- Organic reactions
Background:
- Radical thiol-yne coupling (TYC) is a highly efficient click chemistry reaction.
- TYC is a metal-free alternative to reactions like Cu-catalysed azide-alkyne cycloaddition (CuAAC).
- TYC offers advantages over thiol-ene coupling (TEC) in efficiency and derivatization.
Purpose of the Study:
- To review recent advancements in radical thiol-yne coupling.
- To highlight the applications of TYC in materials chemistry and bioconjugation.
- To showcase TYC as a versatile click chemistry method.
Main Methods:
- Review of recent scientific literature on radical thiol-yne coupling.
- Analysis of mechanistic features and reaction efficiencies.
- Exploration of applications in materials science and bioconjugation.
Main Results:
- Radical TYC demonstrates high efficiency and selectivity.
- TYC is suitable for metal-free bioconjugation and complex material synthesis.
- Recent studies show multifaceted derivatizations are achievable with TYC.
Conclusions:
- Radical TYC is a powerful and versatile click chemistry reaction.
- TYC is a promising method for biomedical applications and advanced materials.
- Further exploration of TYC in diverse chemical fields is warranted.
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